Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs
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A comparative evaluation on E-cadherin expression in oral squamous cell carcinoma with and without regional lymph node metastasis
A comparative evaluation on E-cadherin expression in oral squamous cell carcinoma with and without regional lymph node metastasis Dr. N. Mohtasham* - Dr. A. Omidi**- Dr. K. Kamyabhesari*** - Dr. M. Shakeri**** *- Assistant Professor of Oral Pathology Dept. - Faculty of Dentistry – Mashhad University of Medical Sciences. **- Professor of Pathology Dept. – Ghaem Hospital. ***- Fellowship of Derma...
متن کاملtranscriptional suppression of e-cadherin by hpv-16 e6 and e7 oncogenes is independent of hypermethylation of e-cadherin promoter
results hpv-16 e6 and e7 proteins reduced e-cadherin expression 3.7 and 2.2 times when compared with control cells (p = 0.0221 and p = 0.0461, respectively). this reduction was greater in hpv-16 e6-expressing cells than in hpv-16 e7-expressing cells. although hpv-16 e6 and e7 increased dna methyltransferase 1 expression 2.6 and 3.4 times, respectively (p = 0.0133 and p = 0.0113) when compared w...
متن کاملMTA1 promotes metastasis of MPM via suppression of E-cadherin
BACKGROUND Metastasis-associated gene 1(MTA1) has been identified as an oncogene in many tumors, and aberrant MTA1 expression has been linked to carcinogenesis and metastasis. We aim to investigate the mechanism of MTA1 and metastasis in malignant pleural mesothelioma (MPM). METHODS Real-time polymerase chain reaction (PCR) and immunohistochemical staining were employed to detect MTA1 and E-c...
متن کاملTC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is an aggressive type of cancer, and it may be at an advanced stage when it is detected. It has been shown that TC21, a member of the Ras superfamily, is associated with the proliferation, migration and transformation of tumor cells. Previous studies have shown that TC21 is overexpressed in breast, esophageal and oral carcinomas, and that it is closely associated ...
متن کاملRARγ-induced E-cadherin downregulation promotes hepatocellular carcinoma invasion and metastasis
BACKGROUND Aberrant expression of Retinoic acid receptor γ (RARγ) is implicated in cancer development. Our previous study identified that RARγ functions as a tumor promoter to drive hepatocellular carcinoma (HCC) growth. However, its contribution to HCC invasion and metastasis remains unclear. METHODS RARγ expression in clinical HCC samples was detected by western blot and immunohistochemistr...
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ژورنال
عنوان ژورنال: Cell Adhesion & Migration
سال: 2019
ISSN: 1933-6918,1933-6926
DOI: 10.1080/19336918.2019.1638689